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Conversion of Major Ginsenoside Rb(1) to Ginsenoside F (2) by Caulobacter leidyia.

Cheng LQ, Kim MK, Lee JW, Lee YJ, Yang DC

Department of Oriental Medicinal Material & Processing College of Life Science, Kyung Hee University, 1 Seocheon, Kihung Yongin, Kyunggi, 449-701, South Korea, deokchunyang@yahoo.co.kr.

Ginsenoside Rb(1) is the most predominant ginsenoside in Panax species (ginseng) and the hydrolysis of this ginsenoside produces pharmaceutically active compounds. Caulobacter leidyia GP45, one of the isolates having strong beta-glucosidase-producing activity, converted ginsenoside Rb(1) to the active metabolites by 91%. The structures of the resultant metabolites were identified by NMR. Ginsenoside Rb(1) had been consecutively converted to ginsenoside Rd (1), F(2) (2) and compound K (3) via the hydrolyses of 20-C beta-(1-->6)-glucoside, 3-C beta-(1-->2)-glucoside, and 3-C beta-glucose of ginsenoside Rb(1).

Published 5 July 2006 in Biotechnol Lett, 28(14): 1121-7.
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