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The Effects of Ginsenoside Re and its Metabolite, Ginsenoside Rh1, on 12-O-Tetradecanoylphorbol 13-acetate- and Oxazolone-Induced Mouse Dermatitis Models.

Shin YW, Bae EA, Kim SS, Lee YC, Lee BY, Kim DH

College of Pharmacy, Kyung Hee University, Seoul, Korea.

The effects of the main constituent ginsenoside Re in ginseng and its metabolite, ginsenoside Rh1, were investigated in 12- O-tetradecanoylphorbol 13-acetate (TPA)- and oxazolone-induced mouse ear dermatitis models. Ginsenoside Rh1 potently suppressed the TPA- and oxazolone-induced swellings as well as mRNA expression levels of cyclooxygenase-2, IL-1beta and TNF-alpha, although these were only weakly inhibited by ginsenoside Re. TPA:12-O-tetradecanoilphorbol 13-acetate COX:cyclooxygenase TNF-alpha:tumor necrosis factor-alpha IL-1beta:interleukin-1beta.

Published 24 March 2006 in Planta Med, 72(4): 376-8.
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