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In vivo rat metabolism and pharmacokinetic studies of ginsenoside Rg3.

Qian T, Cai Z, Wong RN, Mak NK, Jiang ZH

Department of Chemistry, Hong Kong Baptist University, 224 Waterloo Road, Kowloon, Hong Kong, SAR, China.

Metabolism of an anti-tumor active component of Panax ginseng, ginsenoside (20R)-Rg(3), was studied for better understanding its pharmacokinetics in rat. LC-MS was used to determine Rg(3) and its metabolites in rat plasma, urine and feces samples. An average half-life of 18.5 min was obtained after the ginsenoside was intravenously dosed at 5 mg/kg. However, Rg(3) was not detected in rat plasma collected after oral administration at 100 mg/kg. Only 0.97-1.15% Rg(3) of the dosed amount was determined in feces. Hydrolysis and oxygenated metabolites were detected and identified in feces collected after oral administration by using LC-MS and MS-MS.

Published 24 January 2005 in J Chromatogr B Analyt Technol Biomed Life Sci, 816(1): 223-32.
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